MECHANISMS OF DISEASE RESEARCH & RECRUITMENT CONFERENCE

August 4 - 6, 2022

Children's Mercy Park - Kansas City, KS

Discover research advancements, career opportunities, and entry points into industry companies.

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Professional Registration

SCIENTIFIC SESSION TOPICS

Disease & Development


Rare Diseases

Infectious Disease

Genetic Mechanisms

Developmental Genetics & Signaling

Epigenetic Regulation of Gene Expression

Chromosomal & Genome Stability

Computational Biology

Drugs & Pharmacology

Drug Design

Delivery of Molecules & Biologics

Bioanalytical Chemistry

Pharmacology

MEET THE SPEAKERS

Dr. Brian D. Ackley

University of Kansas

Jace Allen

Actalent

Dr. Thomas Beadnell

Eurofins Viracor

Chiswili Yves Chabu

University of Missouri

Dr. Ana Cohen

Children's Mercy Kansas City/The University of Missouri-Kansas City

Julie Deane

KCAS Bioanalytical & Biomarker Services

Dr. Michay Diez

Stowers Institute for Medical Research

Austin Gowen

University of Nebraska Medical Center

Leena Kader

University of Kansas Medical Center

Daniel Lopez

Amgen

Hannah Miller

Kansas State University

Molly Muehlebach

University of Nebraska Medical Center

Dr. Jamie Nutt

Eurofins Viracor

Dana Rademacher

University of Missouri - Kansas City

Allison Schweiker

University of Missouri - Kansas City

Griffin Welfer

University of Kansas Medical Center

Dr. Doug Wright

University of Kansas Medical Center

Dr. Erin E. Young

University of Kansas Medical Center

Dr. David Akinbo

Kansas State University

Asha Rankoth Arachchige

Wichita State University

Alice Bedois

Stowers Institute for Medical Research

Dr. Cynthia Chen

Stowers Institute for Medical Research

Dr. Giovanna Collu

Icahn School of Medicine at Mount Sinai

Gabriel da Silva Pescador

Stowers Institute for Medical Research

Dr. Zachary Fischer

University of Missouri - Kansas City

Rex Hafenstine

Wichita State University

Abigail Kreznor

Kansas State University

Eric Lundstrom

Pfizer

Dr. Daniel Montezano

University of Kansas

Bryan Murphy

University of Kansas Medical Center

Prabhavie Opallage

University of Kansas

Dr. Jennifer Radosevich

Hill's Pet Nutrition

Dr. Olivia Veatch

University of Kansas Medical Center

Valerie Welter

Pfizer

Dr. Gerald Wyckoff

Zorilla Research/University of Missouri-Kansas City

Dr. Bing Zhang

University of Missouri

Nadia Alissa

University of Kansas Medical Center

Samalee Banerjee

University of Kansas

Luciana Castellano

Stowers Institute for Medical Research

Dr. Michael Coe

Phoreus Biotechnology Inc.

Lauren Conaway

InnovateHER KC

Manisha Diaz

Eurofins Viracor

Chamandi Dampalla Gamachchige

Wichita State University

Komal Hatti

Integrated Project Services

Dr. Nuria Lara

University of Missouri - Kansas City

Hyma Mandapaka

Wichita State University

Mai Mostafa

University of Nebraska Medical Center

Karen Ninemire

Integrated Project Services, LLC

Nadia Patterson

University of Missouri - Columbia

Benjamin Ryan

University of Kansas Medical Center

Sridhar Vemulapalli

University of Nebraska Medical Center

Jim West

Clara Bio

Dr. Pravin Yeapuri

University of Nebraska Medical Center

CONFERENCE SCHEDULE

Thursday, August 4

1:00-2:00 pm

Registration

Location: UMB Premium Entry

2:00-3:30 pm

Drugs & Pharmacology

Location: Executive Lounge

2:00-3:15 pm

Genetic Mechanisms

Location: Shield Club

2:00 pm

Monocyte biomarkers define sargramostim treatment outcomes for Parkinson’s disease

2:15 pm

Development of an extended half-life GM-CSF fusion protein for Parkinson’s disease

2:30 pm

Two Novel, Peptide-Based Nanoparticle Carrier Platforms for Delivery of Nucleic Acid Constructs and Traditional Hydrophobic Small Molecule Active Ingredients

2:45 pm

Disease Profiling & Delivery of Molecules and Biologics through Extracellular Vesicles

3:00 pm

The effects of novel GGDPS inhibitor RAM2061 on pre-osteoclasts and mature osteoclasts in vitro

2:00 pm

iCodon: Harnessing mRNA Stability to Customize Gene Expression

2:15 pm

Genome wide gene expression and chromatin accessibility discovery at single cell resolution

2:30 pm

Using Machine Learning to Predict Subcellular Morphology of Endothelial Cells: Gaining insight into the Mechanisms of Disease through Mechanobiology

2:45 pm

Bacterial Outer Membrane Proteins

3:00 pm

NMR Structural and Dynamics Studies of an Insect Cytokine-like Stress Responsive Peptide

3:15 pm

The Impact of Avpr1a Expression and Host-Microbiome Interactions on Visceral Hypersensitivity.

3:30-4:00 pm

Keynote

Location: Shield Club

Keynote

4:00-6:30 pm

Poster Session & Refreshments

Location: UMB Premium Entry & Shield Club

Session 1 – Even Numbered Abstracts

4:00 – 5:15 pm

100   Investigating codon-dependent regulation of host gene expression during Dengue infection

102   Characterizing structural deviations between essential lipoprotein chaperone homologs in the periplasm

104   Design and synthesis of 3-chymotrypsin like protease inhibitor of SARS-CoV-2

106   The Tyrosine Hydroxylase in Dopaminergic Neuron Cells Lead to Increased Oxidative Stress and Cell Death by Activation of Acidosis

108   Mutations in genes involved in nutrient uptake and metabolism destabilize cooperation in the bacterium Pseudomonas aeruginosa

200   Developing a 3D-Printed Microfluidic Device for Quantitative Analysis of Glioblastoma Migration in Controllable Chemical Gradients

202   Longitudinal Monitoring of Circulating Tumor Cells (CTCs) in Pancreatic Cancer Patients Treated with Novel Therapies

204   Changing non-polar amino acid  glycine to polar aspartic acid in LDH and studying its effect on binding constant

206   Resistive-Pulse Sensing of Single Peptide Molecules using Dual In-plane Nanopores

208   Monocyte biomarkers define sargramostim treatment outcomes for Parkinson’s disease

210   Utilizing Fluorescence Cross-Correlation Spectroscopy to Study Weak Protein-Micelle Interactions

212   Tumor-derived CCL2 Contributes to Cachexia During Breast Cancer Progression

300 Role of Estrogen Receptor α in Bone and Muscle Crosstalk across Aging

 

302   Leaving the nest: riddance of maternal proteins for embryonic development

304   Sexual Dimorphism: Investigating Genetic Mechanisms in Jaw Bone Development

306   TGF-ß1 is Associated with Impaired Polymorphonuclear Cell Functions in Sickle Cell Disease

308   Resolution of Aberrant Gene Targeting Events and Complex Genomic Rearrangements in Mouse Disease Models Using Long Read Sequencing 

310   The Impact of Avpr1a Expression and Host-Microbiome Interactions on Visceral Hypersensitivity.

312   Gene co-expression and machine learning approach to compare SARS-CoV-2 infected tissues in humans

314   Quorum Sensing Regulation by the Nitrogen Phosphotransferase System in Pseudomonas aeruginosa

400   Exercise Attenuates Hindpaw Hypersensitivity, Depression-like Behaviors, and Morphological Changes in the Hippocampus of Mice Exposed to Early Life Stress

402   Time-of-Flight Identification of Deoxyribonucleotide Monophosphates (dNMP) Molecules Using Dual In-Plane Nanopore Device

Session 2 – Odd Numbered Abstracts

5:15 – 6:30 pm

101   Structure-guided Design of Potent and Permeable Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-Like Protease

103   Identifying the mechanism of PARP14-mediated host interferon response and Coronavirus replication inhibition

105   Using XL-MS to identify the palladin-actin binding interface and elucidate palladin’s role in cancer metastasis

107   Monocyte chemoattractant protein-1 is a serum biomarker to study muscle disease in the Duchenne muscular dystrophy canine model

201   Characterization of PET tracer Flutemetamol (GE-067) binding to Aβ1-40 fibrils

203   HRMS/MS-based approach for separation and quantification of amino acids by chemical isotope-labeled Marfey’s reagent

205   Neurochemical characterization of Parkinson’s disease model zebrafish

207   Alcohol/HIV-1 Tat Induced Neurodeficit: Possible Treatment PPAR y Agonist

209   Boronic acid as a versatile handle for enriching cross-linked peptides

211   Development of a theranostic agent for diagnosis and treatment of high-risk neuroblatoma in children

213   The effects of novel GGDPS inhibitor RAM2061 on pre-osteoclasts and mature osteoclasts in vitro

215   Direct detection of inorganic ions and underivatized amino acids in biological samples using planer capillary electrophoresis coupled with back- scatter interferometry

301   Myopalladin charge neutralization mutations affect actin binding

303   PDCD4 as a biomaker for melanoma brain metastasis

305   Regulation of sleep by two cholinergic neurons located in the Ventral Nerve Cord of Drosophila

307   iCodon: Harnessing mRNA Stability to Customize Gene Expression

309   RSL3, a Potential Cell pathogenesis and Ferroptosis driver in the study of SLE

311 – The Role of Cytonemes in Ras-mediated Tumor Overgrowth

313   Site search process and the mechanism of synaptosome assembly

401 – Impact of Spaceflight and Microgravity on the Glucocorticoid Pathway and Adrenal Gland in mice flown on the International Space Station

403   Defining the interface between palladin and actin using crosslinking mass spectrometry

6:30 pm

Buses Depart

Location: UMB Premium Entry

Friday, August 5

7:00-8:00 am

Breakfast & Registration

Location: UMB Premium Entry

8:00-8:30 am

Keynote

Location: Executive Lounge

The importance of belonging and inclusion in STEM

8:30-10:00 am

Genetic Mechanisms

Location: Executive Lounge

8:30-10:00 am

Drugs & Pharmacology

Location: Shield Club

8:30 am

Site search process and the mechanism of synaptosome assembly

8:45 am

TGF-ß1 is Associated with Impaired Polymorphonuclear Cell Functions in Sickle Cell Disease

9:00 am

Structural Characterization of DNA Polymerase Beta Processing Damaged Nucleosomal DNA

9:15 am

Investigating the impact of ribonucleotides in telomeres and their role in human disease

9:30 am

Usage of Drosophila as a model organism to investigate conserved pathways in insulin signaling

9:45 am

TBA

8:30 am

Developing a 3D-Printed Microfluidic Device for Quantitative Analysis of Glioblastoma Migration in Controllable Chemical Gradients

8:45 am

High-density protein cross-linking by combining non-specific cross-linkers to study protein structures by cross-linking mass spectrometry

9:00 am

Direct detection of inorganic ions and underivatized amino acids in biological samples using  planer capillary electrophoresis coupled with back- scatter interferometry

9:15 am

Tumor-derived CCL2 Contributes to Cachexia During Breast Cancer Progression

9:30 am

Considerations on the use of machine learning for health science applications; Pharmacovigilance, Cancer Screening, and beyond

10:00-10:30 am

Coffee Break

Location: The Concourse

10:30 am – 12:30 pm

An Industry of Impact

Location: Executive Lounge

10:30 am

Developing Kansas Talent to Make a Global Impact at Pfizer

10:45 am

Transforming Lives through Innovation at Hill’s Pet Nutrition

11:00 am

Eurofins-Viracor – Specialty Diagnostics for the most critical patients

11:15 am

Advancing science and your career at KCAS

11:30 am

Amgen Talks Biotech

11:45 am

Actalent: Career Partner for Life

12:00 pm

Our Knowledge, Skill, and Passion begin with YOU!

12:15 pm

TBA

12:30 pm – 1:45 pm

Round Table Discussions & Lunch

Location: The Brewhouse

1:45-2:30 pm

Disease & Development

Location: Executive Lounge

1:45 pm

Inclusive and Comprehensive Genomic Medicine for Rare Diseases – the GA4K Experience

2:00 pm

Neonatal Abstinence Syndrome: A Head Start on Brain Injury

2:15 pm

Characterizing mycobiomes in domestic dogs

2:30-3:00 pm

Coffee Break

Location: The Concourse

3:00 – 5:00 pm

Genetic Mechanisms

Location: Executive Lounge

3:00 – 5:00 pm

Development & Disease

Location: Shield Club

3:00 pm

Genetic determinants of inflammatory hypersensitivity: Identification of novel inflammatory pain genes suggests novel non-opioid therapeutic targets

3:15 pm

Myopalladin charge neutralization mutations affect actin binding

3:30 pm

Evolution of the role of Retinoic Acid in vertebrate hindbrain segmentation

3:45 pm

Leaving the nest: riddance of maternal proteins for embryonic development

4:00 pm

Role of Estrogen Receptor α in Bone and Muscle Crosstalk across Aging

4:15 pm

Proteasome Subunit Alpha 2: A Potential Target for Treatment Resistant Prostate Cancer

4:30 pm

Calculating Genetic Risk for Dysfunction in Pleiotropic Biological Processes Using Whole Exome Sequencing Data

4:45 pm

Targeting Drug Resistance Mechanisms in RAS Tumors

3:00 pm

Characterizing structural deviations between essential lipoprotein chaperone homologs in the periplasm

3:15 pm

The exon-junction complex factor CASC3 forms phase-separated granules with antiviral activity towards Turnip crinkle virus

3:30 pm

Investigating codon-dependent regulation of host gene expression during Dengue infection

3:45 pm

Structure-guided Design of Potent and Permeable Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-Like Protease

4:00 pm

Quorum Sensing Regulation by the Nitrogen Phosphotransferase System in Pseudomonas aeruginosa

4:15 pm

How Peripheral Nerves Can Protect Us in Disease

4:30 pm

Age-related Synaptic Degeneration in Nematode Tauopathy Models

4:45 pm

Innovative Clinical Diagnostics

5:00 pm

iLAB – Intelligent Lean Lab

5:15-5:45 pm

Keynote

Location: Executive Lounge

Harnessing a multi-faceted diagnostic approach to support clinical trials for SARS-COV-2 therapeutic strategies

6:00 pm

Buses Depart

Location: UMB Premium Entry

Saturday, August 6

11:00 am

Doors Open

11:30

Act 1

12:30

Act 2

1:30

Act 3

2:30

Act 4

3:30

Act 5

4:40

Act 6

6:05

Act 7

7:30

Act 8

9:15

Act 9